In this TUMS Q&A episode, we'll delve into the factors that put individuals at a higher risk of developing osteoporosis. Osteoporosis, a condition characterized by weakened bones, is a significant health concern, particularly among the elderly. Individuals who have been bedridden for extended periods, those with low body weight, and those with poor nutrition are more susceptible to osteoporosis. Additionally, medications such as warfarin, heparin, and corticosteroids, often prescribed to treat various conditions, can contribute to bone loss. Therefore, early detection and prevention of the adverse effects of these drugs, especially in patients with rheumatic diseases or thyroid disorders (hyperthyroidism and hypothyroidism), is crucial. Cancer patients are also at an increased risk. Dr. Ahmad reza Jamshidi, the Head of the Rheumatology Research Center at Tehran University of Medical Sciences, will provide a comprehensive overview of this topic.